The reference site for Glyburide

Glibenclamide (AAN, BAN, INN), also known as glyburide (USAN), is an antidiabetic drug in a class of medications known as sulfonylureas, closely related to sulfonamide antibiotics.

WHAT IS Glyburide?

Glyburide is in a class of drugs called sulfonylureas. It is used to help control blood sugar levels.

Moreover, glyburide is used to treat type 2 (noninsulin-dependent) diabetes (formerly known as ‘adult-onset’), particularly in people whose diabetes cannot be controlled by diet alone.

Glyburide manages to lower blood sugar levels by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must produce insulin for this medication to work. Glyburide is not used to treat type 1 (insulin-dependent) diabetes (formerly ‘juvenile-onset’).


Brand Name(s): Diabeta; Glynase; Micronase
CAS nº: 10238-21-8
(glye’ byoor ide)


Product Info

The sections below will provide you with more specific information and guidelines related to glyburide and its correct use. Please read them carefully.

FDA Information

Glyburide has been approved by the FDA to reduce blood glucose level.

This medication must always be prescribed by your doctor.

Why is this medication prescribed?

Glyburide is in a class of drugs called sulfonylureas. It is used to help control blood sugar levels. Glyburide lowers the sugar level by stimulating insulin secretion in the pancreas. Insulin is a hormone which lowers the blood sugar level.

Glyburide is also used to treat type 2 diabetes along with diet, exercise, and insulin therapy, if necessary.

Note: Approximately 90% of patients with diabetes have type 2 or non-insulin dependent diabetes mellitus. Type 2 diabetes usually occurs in adulthood, and is associated with obesity and a strong family history of the disease. Sugar (glucose) intolerance is related to impaired insulin secretion by the pancreas and resistance to insulin at the cell level.

Other uses for this medicine

This medication is sometimes prescribed for other uses, but you must always ask your doctor or pharmacist for more information before taking it.

Dosage and using this medicine

Usually your doctor will prescribe an initial daily dose of 2.5 to 5 milligrams. Maintenance therapy usually ranges from 1.25 to 20 milligrams daily. Daily doses greater than 20 milligrams are not recommended.

In most cases, Micronase® is taken once a day, however, people taking more than 10 milligrams a day may respond better to twice-a-day dosing.

Take glyburide exactly as directed by your doctor. Never change your dose of glyburide without first talking to your doctor.

Take each dose with a full glass of water.

Glyburide is usually taken before breakfast or the first main meal if it is taken once a day, or before meals if it is taken multiple times each day. Follow your doctor’s instructions.

It is important to take glyburide regularly to get the most benefit.

Your healthcare provider may recommend regular monitoring of blood sugar levels with blood or urine tests.

What special precautions should I follow?


Before using this medication, tell your doctor and pharmacist if you are allergic to glyburide or any other drugs.

It is important to always inform your doctor and pharmacist what prescription and non-prescription medications you are taking, especially antibiotics, anticoagulants (‘blood thinners’) such as warfarin (Coumadin), dexamethasone (Decadron), diuretics (‘water pills’), estrogens, isoniazid (INH), MAO inhibitors [phenelzine (Nardil) and tranylcypromine (Parnate)], medications for high blood pressure or heart disease, metformin (Glucophage), niacin (nicotinic acid), oral contraceptives, phenytoin (Dilantin), prednisone, probenecid (Benemid), and vitamins.

Tell your doctor if you have or have ever had heart or kidney disease.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking glyburide, call your doctor immediately.

If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking glyburide.

You should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you. Remember that alcohol can also add to the drowsiness effect caused by this drug.

Tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of glyburide.

Try to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Glyburide may make your skin sensitive to sunlight.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose.

Never take a double dose of this medication.

What side effects can this medication cause?

Common side effects from glyburide use:


Tell your doctor if any of these symptoms are severe or do not go away:

nasal congestion
runny nose
stomach pain

If you experience any of the following symptoms, call your doctor immediately:

skin rash or hives
itching or redness
exaggerated sunburn
yellowing of the skin or eyes
light-colored stools
dark or clay-colored urine
unusual bleeding or bruising
sore throat

Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):

extreme thirst
frequent urination
extreme hunger
blurred vision

Eat or drink a food or beverage with sugar in it, such as hard candy or fruit juice, and call your doctor immediately if you begin to suffer any of the symptoms of hypoglycemia (low blood sugar) listed below:

dizziness or lightheadedness
nervousness or irritability
sudden changes in behavior or mood
numbness or tingling around the mouth
pale skin
sudden hunger
clumsy or jerky movements

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed. If you have any queries, please talk with your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

cold sweats


Product Images


Below you will find images and specific information on the principal types of glyburide that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Strength(s): 1.25 MG
Imprint: MICRONASE 1.25
Manufacturer: PHARMACIA/UPJHN.

Strength(s): 1.5 MG
Imprint: MO3 1.5 | MOVA
Manufacturer: MOVA PHARM.

Strength(s): 1.5 MG
Imprint: M 113
Manufacturer: MYLAN

Strength(s): 2.5 MG
Imprint: G 3726
Manufacturer: GREENSTONE LTD.

Strength(s): 2.5 MG
Imprint: N 343 | 2.5
Manufacturer: NOVOPHARM

Strength(s): 2.5 MG
Imprint: cor 124
Manufacturer: SANDOZ

Strength(s): 3 MG
Imprint: G 3782
Manufacturer: GREENSTONE LTD.

Strength(s): 3 MG
Imprint: GLYNASE 3 | PT PT
Manufacturer: PHARMACIA/UPJHN.

Strength(s): 3 MG
Imprint: MO4 3.0 | MOVA
Manufacturer: MOVA PHARM.

Strength(s): 5 MG
Imprint: cor 125
Manufacturer: SANDOZ

Strength(s): 5 MG
Imprint: GLYBUR | 364 364
Manufacturer: TEVA USA

Strength(s): 6 MG
Imprint: G 3783
Manufacturer: GREENSTONE LTD.

Strength(s): 6 MG
Imprint: MO7 6.0 | MOVA
Manufacturer: MOVA PHARM.

Strength(s): 6 MG
Imprint: GLYNASE 6 | PT PT
Manufacturer: PHARMACIA/UPJHN.

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